Cross-linked enzymatically controlled drug release
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United States of America Patent
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Feb 18, 1997
Issued Date -
N/A
app pub date -
Jun 16, 1994
filing date -
Nov 27, 1990
priority date (Note) -
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Abstract
The present application is concerned with a solid slow release pharmaceutical dosage unit. More specifically, the invention is directed to a tablet form prepared by direct compression of cross-linked amylose (CLA) having a definite cross-linking degree, .alpha.-amylase and a pharmaceutical agent. The presence of the cross-linked amylose allows a sustained release of the drug, while the .alpha.-amylase permits the modulation of the release time. In other words, the release time of the drug is function of the amount of .alpha.-amylase in the tablet. The amount of .alpha.-amylase is defined in terms of Enzyme Units.
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