Topical administration of toremifene and its metabolites

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United States of America Patent

PATENT NO 5605700
SERIAL NO

08313103

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Abstract

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Transdermal preparations containing as active ingredient toremifene or one of its metabolites N-demethyltoremifene or 4-hydroxy-toremifene or their pharmaceutically acceptable non-toxic salts are useful for the treatment of cancers localized in the skin or on a short distance form the skin such as metastatic lesions of breast cancer. They may also be used in adjuvant therapy of breast cancer and in the reversal of multidrug resistance of cancer cells to cytotoxic drugs. Such transdernal preparations are of particular interest in the treatment of melanoma, lymphoma, Kaposi's sarcoma and fungoides mycosis.

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Patent Owner(s)

Patent OwnerAddress
ORION CORPORATION02200 ESPOO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DeGregorio, Michael W Granite Bay, CA 10 121
Kurkela, Kauko O A Espoo, FI 19 396

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