Recombinant human anti-human immunodeficiency virus antibody
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United States of America Patent
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Mar 4, 1997
Grant Date -
N/A
app pub date -
Jul 13, 1994
filing date -
Aug 24, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides human monoclonal antibodies, derived from the murine mAb NM-01 (PCT/US92/07111), which are specifically reactive with HIV gp120 and have the capacity to neutralize the infection of H9 cells in culture by live HIV-1 strains MN and III.sub.B as shown by reverse transcriptase, p24 and syncytium formation assays. These antibodies were shown to be as or more effective than the parent murine antibody by the aforementioned criteria.
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