Treatment methods using metal-binding targeted polypeptide constructs

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United States of America Patent

PATENT NO 5609847
SERIAL NO

08480370

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Abstract

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The invention relates to a method of treating a patient in need thereof, including a need for diagnosis or treatment, comprising the administration of a metal complex of a polypeptide construct. The construct comprises a compound of the formula (I): ##STR1## in which, 'B' is a hydrocarbon backbone, 'P' is a polypeptide capable of targeting particular-cells, tissues or organs of the body, 'A' may be the group --NR'--NR'-- or the group --NR'--NR'--L-- in which L may be an aliphatic or aromatic linker group, R, R', and R' may be the same or different and may be hydrogen or an aliphatic group, m is an integer .gtoreq.2, provided that the groups R, R', R', L and 'P' of a given chain may be the same or different from the groups R, R', R', L and 'P' of another chain, n is an integer .gtoreq.0; or a pharmaceutically acceptable salt thereof. The constructs of the present invention are capable of binding a variety of metallic species.

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Patent Owner(s)

Patent OwnerAddress
CYTOGEN CORPORATIONPRINCETON NJ

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alvarez, Vernon L Morrisville, PA 23 1273
Belinka, Jr Benjamin A Kendall Park, NJ 11 472
Coughlin, Daniel J Robbinsville, NJ 22 1057
Wood, Richard Rocky Hill, NJ 58 1418

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