Microspheres for the controlled release of water-soluble substances and process for preparing them
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United States of America Patent
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Mar 11, 1997
Issued Date -
N/A
app pub date -
Jul 26, 1995
filing date -
Feb 22, 1990
priority date (Note) -
Expired
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Abstract
Microspheres which are a matrix of a biocompatible and biodegradable polymer which is soluble in an organic solvent which is immiscible in water, within which a water-soluble substance is uniformly distributed, and wherein the residual level of toxic solvent in the microspheres is lower than 1.5% by weight, progressively and continuously releases the substance over a period of at least 8 days when the microspheres are placed in an aqueous physiological environment, with a reduced or substantially absent first phase of accelerated release. A process for producing such microspheres is provided.
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