Methods of preventing viral replication
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United States of America Patent
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Mar 11, 1997
Issued Date -
N/A
app pub date -
Apr 23, 1993
filing date -
Apr 20, 1990
priority date (Note) -
Expired
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Abstract
The invention relates to methods and compositions for inhibition of viral replication. In particular, termination of replication of hepatitis B virus is achieved by introducing into a target cell an antisense oligonucleotide having a sequence substantially complementary to an mRNA which is in turn complementary to a portion of the minus strand of a hepatitis viral genome, which portion encoding solely part or all of the terminal protein region of the viral polymerase.
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