Antibodies for modulating heterotypic E-cadherin interactions with human T lymphocytes
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United States of America Patent
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Mar 11, 1997
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app pub date -
May 3, 1994
filing date -
May 3, 1994
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Abstract
The invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically bind to E-cadherin and isolated peptides which mimic the binding function of E-cadherin also are provided. The antibodies and peptides are useful in screening assays to identify pharmaceutical lead compounds which are capable of modulating adhesion between T lymphocytes and E-cadherin expressing cells. Methods and pharmaceutical compositions for modifying the mucosal immune response of a subject also are provided.
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