Backbone modified oligonucleotide analogues
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United States of America Patent
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Mar 11, 1997
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N/A
app pub date -
Apr 7, 1994
filing date -
Jul 27, 1990
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Abstract
Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly- nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.
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