Active carbonates of polyalkylene oxides for modification of polypeptides
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United States of America Patent
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Mar 18, 1997
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app pub date -
Feb 17, 1994
filing date -
Apr 19, 1989
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Abstract
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.
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