Controlled release preparation
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United States of America Patent
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Mar 25, 1997
Grant Date -
N/A
app pub date -
Mar 16, 1994
filing date -
Mar 30, 1993
priority date (Note) -
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status (Latency Note)
Importance
Abstract
An oral controlled release pharmaceutical preparation in the form of a tablet, capsule or sachet containing a plurality of coated particles comprising a therapeutically effective amount of a salt of morphine coated with a barrier membrane providing a controlled, preferably pH-independent, release of morphine in that the serum concentration of morphine obtained is at least 50% of the maximum serum concentration during at least 12 hours after administration of a single dose, and providing a significantly reduced plasma concentration fluctuation compared to known morphine preparations. A method for the manufacture of such a preparation and the use of such preparations for the manufacture of an analgesic useful in the treatment of severe chronicle pain are also provided.
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