Quinolone derivatives

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United States of America Patent

PATENT NO 5614532
SERIAL NO

08244342

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A class of 2-(1H)-quinolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARPE & DOHME LTDHERTFORD ROAD HODDESDON HERTFORDSHIRE EN11 9BU

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carling, William R Bishops Stortford, GB3 32 200
Leeson, Paul D Cambridge, GB3 27 524
Moore, Kevin W Buntingford, GB3 50 693
Rowley, Michael Harlow, GB3 48 649

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