Method of preventing NMDA receptor-mediated neuronal damage

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United States of America Patent

PATENT NO 5614560
SERIAL NO

08419672

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Abstract

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Disclosed is a method for reducing non-ischemic NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a compound of the formula shown in FIG. 1 (or a physiologically-acceptable salt thereof), wherein R.sub.1 includes an amino group, R.sub.2 -R.sub.17 are independently H or a short chain aliphatic group comprising 1-5 carbons, and R.sub.4 and R.sub.10 also may (independently) be a halogen or an acyl group. Also disclosed is a screen for antagonists of NMDA receptor mediated neurotoxicity which have an enhanced prospect for being clinically tolerated and selective against such neurotoxicity.

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Patent Owner(s)

  • CHILDREN'S MEDICAL CENTER CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lipton, Stuart A Newton, MA 47 667

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