Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
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United States of America Patent
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Mar 25, 1997
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N/A
app pub date -
Feb 18, 1993
filing date -
Jul 27, 1990
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Abstract
Oligonucleotide analogs are provided having improved nuclease resistance. Modifications of selected nucleotides through substitutions on the pyrimidine ring are disclosed. Certain preferred embodiments comprise the inclusion of said modified nucleotides at a plurality of sites, especially at the 3' end of a selected oligonucleotide analog.
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