Ribozyme-mediated inhibition of bovine leukemia virus
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United States of America Patent
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Apr 1, 1997
Issued Date -
N/A
app pub date -
Aug 28, 1995
filing date -
Nov 5, 1993
priority date (Note) -
Expired
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Abstract
A ribozyme is provided which is capable of cleaving bovine leukemia virus (BLV) RNA both in a cell free system and intracellularly. The ribozyme of the present invention comprises the hammerhead motif flanked by antisense sequences complementary to BLV rex/tax RNA. Introduction of the ribozyme into BLV-infected cells results in inhibition of BLV protein expression, allowing for the control of BLV infection.
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