Stabilized retrovirus compositions
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United States of America Patent
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Apr 1, 1997
Grant Date -
N/A
app pub date -
Sep 15, 1994
filing date -
Sep 15, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides a stabilized virus, which is modified using a stabilizing agent. The invention also provides a process for producing a stabilized virus by culturing viral producing cells with a stabilizing agent at a temperature below 37.degree. C. The invention further provides methods to introduce an exogenous nucleotide sequence into a cell using a stabilized virus containing the exogenous nucleotide sequence. The invention also provides methods for administering an exogenous nucleotide sequence to a subject using a stabilized virus containing the exogenous nucleotide sequence. The invention further provides a method to produce a protein by infecting a cell with a stabilized virus containing a exogenous nucleotide sequence encoding the protein and then isolating the protein produced by the infected cells.
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