Dihydropyridine-3, 5-dicarboxylic acid ester derivatives

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United States of America Patent

PATENT NO 5616715
SERIAL NO

08491793

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Abstract

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A process is provided for producing diastereoisomer A or a pharmaceutically acceptable acid addition salt of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester which comprises subjecting a mixture of diastereoisomers A and B of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester to column chromatography using silica gel as a carrier and a mixture of ethyl acetate and acetic acid as an eluant, and then separating the acetate of diastereoisomer A from the eluate, or treating the acetate with a base, or further treating the resulting diastereoisomer A with a pharmaceutically acceptable acid.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ASTELLAS PHARMA INC.TOKYO290

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arima, Hideki Tokyo, JP 6 32
Isomura, Yasuo Tokyo, JP 29 321
Kojima, Tadao Saitama, JP 14 79
Murakami, Yukiyasu Saitama, JP 13 50
Okada, Minoru Tokyo, JP 117 1881
Takanobu, Kiyoshi Saitama, JP 3 6
Takenaka, Toichi Tokyo, JP 15 112
Tamazawa, Kazuharu Saitama, JP 4 6

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MEAD JOHNSON & COMPANY (1)
* 4463176 Process for resolution of optical isomers 10 1982
* Cited By Examiner

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