US Patent No: 5,616,715

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Dihydropyridine-3, 5-dicarboxylic acid ester derivatives

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Abstract

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A process is provided for producing diastereoisomer A or a pharmaceutically acceptable acid addition salt of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester which comprises subjecting a mixture of diastereoisomers A and B of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester to column chromatography using silica gel as a carrier and a mixture of ethyl acetate and acetic acid as an eluant, and then separating the acetate of diastereoisomer A from the eluate, or treating the acetate with a base, or further treating the resulting diastereoisomer A with a pharmaceutically acceptable acid.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ASTELLAS PHARMA INC.TOKYO532

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arima, Hideki Tokyo, JP 6 29
Isomura, Yasuo Tokyo, JP 29 289
Kojima, Tadao Saitama, JP 14 59
Murakami, Yukiyasu Saitama, JP 11 29
Okada, Minoru Tsukuba, JP 139 967
Takanobu, Kiyoshi Saitama, JP 3 6
Takenaka, Toichi Tokyo, JP 15 107
Tamazawa, Kazuharu Saitama, JP 4 6

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Mead Johnson & Company (1)
4,463,176 Process for resolution of optical isomers 9 1982

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