Biodegradable polymer matrices for sustained delivery of local anesthetic agents
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United States of America Patent
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Apr 8, 1997
Issued Date -
N/A
app pub date -
Sep 10, 1993
filing date -
Sep 10, 1992
priority date (Note) -
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Abstract
An improved biodegradable controlled release system consisting of a polymeric matrix incorporating a local anesthetic for the prolonged administration of the local anesthetic agent, and a method for the manufacture thereof, are disclosed. The polymers and method of manufacture used to form the PLAMs are selected on the basis of their degradation profiles: release of the topical anesthetic in a linear, controlled manner over a period of preferably two weeks and degradation in vivo with a half-life of less than six months, more preferably two weeks, to avoid localized inflammation. Alternatively, a non-inflammatory can be incorporated into the polymer with the local anesthetic to prevent inflammation.
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