Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
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United States of America Patent
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Apr 8, 1997
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Sep 2, 1994
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Jul 27, 1990
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Abstract
Methods for preparing oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. In preferred embodiments, the methods involve radical coupling of 3'- and 5'-substituted or 5'- and 3'-substituted nucleosidic synthons.
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