Combinatorial sulfonamide library
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United States of America Patent
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Apr 8, 1997
Issued Date -
N/A
app pub date -
Jun 7, 1995
filing date -
Mar 11, 1994
priority date (Note) -
Expired
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Abstract
Combinatorial libraries are disclosed which are represented by Formula I: (T'--L).sub.q -- S--C(O)--L'--II' I wherein: S is a solid support; T'--L-- is an identifier residue; and --L'--II' is a ligand/linker residue. Compounds which contain aryl sulfonamides, N-acyl derivatives, and N-substituted pyrrolidines and piperidines of the formula: Y--A--CO--R.sup.1 are inhibitors of serine proteases and carbonic anhydrase isozymes. They are useful in the treatment of hyper-coagulation disease and ocular diseases such as glaucoma.
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