US Patent No: 5,620,687

Number of patents in Portfolio can not be more than 2000

Inhibition of intimal hyperplasia using antibodies to PDGF beta receptors

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Abstract

Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an anti-PDGF receptor antibody, such as an anti-PDGF-alpha receptor antibody or an anti-PDGF-beta receptor antibody. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft. The anti-PDGF receptor antibodies may optionally be administered coordinately with heparin, whereby the coordinately administered antibody and heparin are combinatorially effective in inhibiting intimal hyperplasia.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
UNIVERSITY OF WASHINGTONSEATTLE, WA1063
ZYMOGENETICS, INC.SEATTLE, WA598

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Clowes, Alexander W Seattle, WA 5 26
Hart, Charles E Woodinville, WA 76 417
Kenagy, Richard D Seattle, WA 4 24

Cited Art

Patent Info (Count) # Cites Year
 
ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. (1)
5,171,217 Method for delivery of smooth muscle cell inhibitors 269 1991
 
COR THERAPEUTICS, INC. (1)
5,268,358 PDGF receptor blocking peptides 56 1991
 
GLYCOMED INCORPORATED (1)
5,250,519 Non-anticoagulant heparin derivatives 11 1991
 
ZYMOGENETICS, INC. (1)
5,155,027 Method of producing secreted receptor analogs and biologically active peptide dimers 71 1989

Patent Citation Ranking

Forward Cites

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BOSTON SCIENTIFIC SCIMED, INC. (2)
6,695,830 Method for delivering medication into an arterial wall for prevention of restenosis 8 2001
8,066,690 Method for delivering medication into an arterial wall for prevention of restenosis 0 2010
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (2)
6,489,134 Kinesin motor modulators derived from the marine sponge Adocia 3 2000
6,777,200 Kinesin motor modulators derived from the marine sponge Adocia 0 2002
 
AMGEN FREMONT INC. (1)
7,993,643 Uses of human monoclonal antibodies against oxidized LDL receptor 0 2007
 
IMCLONE LLC (1)
7,740,850 PDGFRβ-specific antibodies 0 2008
 
OMEROS CORPORATION (1)
5,800,385 Vascular irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis 64 1996
 
PHILADELPHIA HEALTH & EDUCATION CORPORATION D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE (1)
8,425,911 Methods of treating secondary bone tumors with antibodies against PDGFR alpha 0 2011
 
PROTEIN DESIGN LABS, INC. (1)
5,882,644 Monoclonal antibodies specific for the platelet derived growth factor .beta. receptor and methods of use thereof 12 1996
 
UNIVERSITY OF WASHINGTON (1)
8,128,929 Antibodies against PDGFRa 0 2006