Inhibition of intimal hyperplasia using antibodies to PDGF beta receptors
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United States of America Patent
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-
Apr 15, 1997
Issued Date -
N/A
app pub date -
Dec 30, 1994
filing date -
Feb 25, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an anti-PDGF receptor antibody, such as an anti-PDGF-alpha receptor antibody or an anti-PDGF-beta receptor antibody. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft. The anti-PDGF receptor antibodies may optionally be administered coordinately with heparin, whereby the coordinately administered antibody and heparin are combinatorially effective in inhibiting intimal hyperplasia.
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