Transfer of taxol from yew tree cuttings into a culture medium over time
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United States of America Patent
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Apr 15, 1997
Grant Date -
N/A
app pub date -
Feb 17, 1995
filing date -
Feb 17, 1995
priority date (Note) -
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Abstract
Taxol, an antineoplastic drug, has shown cytotoxic activity against numerous malignant tumors including: breast cancer, colon cancer, ovarian cancer, and skin cancer. Taxol is found in many species of yew including: slow-growing Taxus brevifolia and faster-growing Taxus media X Hicksii. Yew tree cuttings were cultured and the medium was extracted weekly, bi-weekly, and tri-weekly over a period of nine weeks. Taxol and other taxanes were separated through a multi-step procedure using hexane extractions, C-18 Sep Pak cartridges, and high performance liquid chromatography (HPLC). The concentration of the taxanes was then calculated. Taxol and other taxanes can continue to be transferred into a culture medium and extracted over a nine-week period. There is a higher yield when extracted weekly.
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