Processes and intermediates for preparing macrocycles

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United States of America Patent

PATENT NO 5621108
SERIAL NO

08349413

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Abstract

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Novel processes for the preparation of lactam- and lactone-containing macrocyles are provided. In preferred embodiments, rapamycin and demethoxyrapamycin are prepared by a convergent synthesis regime. Intermediates useful in the synthetic processes are also provided.

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Patent Owner(s)

Patent OwnerAddress
CHEMICAL BANK633 THIRD AVENUE NEW YORK NY 10017

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Condon, Stephen M Philadelphia, PA 61 656
Leahy, James W San Leandro, CA 11 245
Leazer, Jr Johnnie L Philadelphia, PA 4 22
Maleczka, Robert E Media, PA 9 50
McCauley, John A Philadelphia, PA 67 584
Smith, III Amos B Merion, PA 23 137

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