Calixarene conjugates useful as MRI and CT diagnostic imaging agents
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United States of America Patent
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Apr 22, 1997
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N/A
app pub date -
Nov 15, 1994
filing date -
Nov 15, 1994
priority date (Note) -
Expired
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Abstract
Calixarene conjugates useful for imaging, particularly magnetic resonance imaging (MRI) and computed tomography (CT) are described. Said calixarene conjugates comprise (i) a calixarene backbone, and (ii) at least one imaging moiety linked thereto, and may be of the formula: ##STR1## wherein at least one of the R.sup.1 and R.sup.4 substituents comprises an imaging moiety, the remaining R.sup.1 and R.sup.4 substituents are spectator groups, J is an ortho-linker, and n is an integer from 4 to 8. Imaging moieties useful for CT imaging include those comprising two or more iodine atoms. Imaging moieties useful for MRI include (i) organic moieties comprising four or more fluorine atoms; (ii) nitroxyl spin labeled moieties; and (iii) metal chelate moieties.
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