Spheroid formulation
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United States of America Patent
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Apr 22, 1997
Issued Date -
N/A
app pub date -
Dec 5, 1994
filing date -
Feb 20, 1992
priority date (Note) -
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Abstract
A pharmaceutical composition comprising spheroids comprising a water-soluble active ingredient or a pharmaceutically acceptable salt thereof, microcrystalline cellulose and a sugar. Preferably the active ingredient is hydromorphone hydrochloride and the sugar is lactose. Surprisingly the incorporation of a sugar improves the dissolution rate of the spheroid formulation instead of reducing the dissolution rate by competing with the active ingredient for solubilization.
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