Methods and devices for manipulation of magnetically collected material
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United States of America Patent
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Apr 22, 1997
Issued Date -
N/A
app pub date -
Jun 7, 1995
filing date -
Sep 26, 1990
priority date (Note) -
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Abstract
Methods and devices are disclosed which are useful for collecting magnetic materials in either internally or externally generated magnetic gradient fields, followed by resuspension into solution with a simple manipulation of the magnetic device. The methods provide for removal of excess reagent, washing of magnetic material, and resuspension for analysis, among other uses. The methods are applicable to all types of biological material that are susceptible to magnetic labelling, including, for example, cells, viruses, proteins, hormones, and receptor-ligand complexes. Several devices are disclosed to take advantage of the method for cellular and immunoassay applications, including both internal and external devices. Both flow-through and static separators are disclosed.
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