Heteroatomic oligonucleoside linkages
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United States of America Patent
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Apr 22, 1997
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N/A
app pub date -
Feb 27, 1995
filing date -
Jul 27, 1990
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Abstract
Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligonucleotides with three or four atom linking groups provide unique oligonucleotide-mimicking macromolecules that are useful in regulating RNA expression and in therapeutics. Methods of synthesis and use also are disclosed.
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