Antibodies with altered effector functions

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United States of America Patent

PATENT NO 5624821
SERIAL NO

08479752

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Abstract

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An antibody with an altered function, e.g. altered affinity for an effector ligand such as Fc receptor (FcR) on a cell or the C1 component of complement is produced by replacing at least one amino acid residue in the constant portion of the antibody with a different residue.

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Patent Owner(s)

Patent OwnerAddress
SB2 INC905 PEPPERWOOD DRIVE DANVILLE CA 94526

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burton, Dennis R Sheffield, GB3 68 2139
Duncan, Alexander R Wimbledon, GB3 12 1362
Winter, Gregory P Cambridge, GB3 24 5036

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