Chemical compounds as inhibitors of amyloid beta protein production
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United States of America Patent
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Apr 29, 1997
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N/A
app pub date -
Mar 2, 1995
filing date -
Mar 2, 1995
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Expired
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Abstract
A compound of the formula I in which ##STR1## Z is O or S; R.sup.11 is a halogen atom; R.sup.12 is a halogen atom or a trifluoromethyl group; and X is S, SO, SO.sub.2, O or NH; R.sup.4 is naphthyl, quinolinyl, benzimidazolyl, pyridyl, pyradazinyl, benzoxazolyl or benzothiazolyl, unsubstituted or substituted by one or two substituents selected from a halogen atom, (1-4C)alkyl, (1-4C)alkoxy, nitro, (1-4C)alkoxycarbonyl, halo(1-4C)alkyl, and phenyl; or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of amyloid beta-protein production.
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