Preparation of continine by reacting nicotine with bromide and bromate
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United States of America Patent
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Apr 29, 1997
Grant Date -
N/A
app pub date -
Jun 7, 1995
filing date -
Jun 7, 1995
priority date (Note) -
Expired
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Abstract
Cotinine is prepared from nicotine or nicotine sulfate by mixing a solution thereof with compounds having the formula XBr, YBrO.sub.3 where X is hydrogen or an alkali metal and Y is an alkali metal to produce an intermediate product: dibromocotinine hydrobromide perbromide, which is reduced and de-brominated to produce cotinine.
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