Mouse having a disrupted lck gene
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United States of America Patent
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Apr 29, 1997
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N/A
app pub date -
Nov 3, 1993
filing date -
Apr 24, 1992
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Abstract
A mutant non-human mammal lacking expression of the lymphocyte-specific tyrosine kinase p56.sup.lck. Lck deficient mice possess few peripheral T lymphocytes and a pronounced thymic atrophy. The remaining thymus contains immature thymocytes surrounded by a perturbed thymic microenvironment. p56.sup.lck appears to play a crucial role in early thymocyte differentiation.
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