Anti-myosin mouse monoclonal antibody and method of use for diagnosis of myocardial infarction
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United States of America Patent
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May 6, 1997
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app pub date -
May 31, 1994
filing date -
Mar 23, 1989
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Abstract
A monoclonal antibody or antigen binding fragment thereof which recognizes light meromyosin fragments of .alpha.- and .beta.-type human cardiac myosin heavy chains that remain in situ after myocardial cell death is described. The antibody is produced by the hybridoma having the accession number ATCC HB9916. The antibody or antigen binding fragment thereof does not cross-react with human myosin light chains. The monoclonal antibody or antigen binding fragment thereof, in a labeled form is capable of producing an image of both ventricular and atrial damage resulting from myocardial cell necrosis and is capable of producing an image of a cell or tissue expressing myosin.
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