Phosphonic acid compound containing heterocyclic substituents, pharmaceutical composition contains same and a method of treating calcium metabolism disturbance

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United States of America Patent

PATENT NO 5627170
SERIAL NO

08465360

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Abstract

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Compounds of the formula I ##STR1## in which R signifies a possibly substituted amino group of the general formula --NR.sup.1 R.sup.2, whereby, independently of one another, R.sup.1 and R.sup.2 each signify hydrogen, lower alkyl, lower alkenyl or lower alkynyl or R represents a saturated, unsaturated or aromatic heterocyclic ring which can possibly be substituted once or twice by lower alkyl or halogen, alk signifies a valency bond, a methylene, a saturated or unsaturated, straight-chained or branched alkylene chain with 2-6 carbon atoms and R.sup.3, R.sup.4 and R.sup.5, in each case independently of one another, signify hydrogen, lower alkyl or benzyl, as well as their pharmacologically acceptable salts and enantiomers, whereby, for the case that R.sup.3 =R.sup.4 =R.sup.5 =CH.sub.3 and alk signifies a valency bond, R cannot be the dimethylamino group, processes for their preparation and medicaments which contain these compounds for the treatment of calcium metabolism diseases.

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Patent Owner(s)

Patent OwnerAddress
BOEHRINGER MANNHEIM GMBH68305 MANNHEIM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bauss, Frieder Lambsheim, DE 15 123
Bosies, Elmar Weinheim, DE 32 657
Esswein, Angelika Singen, DE 18 93
Tsaklakidis, Christos Weinheim, DE 85 489

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