Integrin-binding peptides
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United States of America Patent
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May 6, 1997
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N/A
app pub date -
Apr 18, 1995
filing date -
Nov 24, 1993
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Abstract
The present invention provides peptides having specificity for fibronectin-binding and vitronectin-binding integrins, and in particular for .alpha..sub.5 .beta..sub.1 integrin. These peptides are characterized by having the ability to interfere with fibronectin binding to .alpha..sub.5 .beta..sub.1 integrin, to block attachment of cells expressing integrins to extracellular matrix proteins and to promote cell attachment when immobilized onto a surface.
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