Composition for nasal administration
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United States of America Patent
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May 13, 1997
Grant Date -
N/A
app pub date -
Jul 12, 1994
filing date -
Feb 5, 1992
priority date (Note) -
In Force
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Importance
Abstract
A composition for nasal administration of polar metabolites of opioid analgesics comprises a polar metabolite of an opioid analgesic and an absorption promoting agent. Preferred metabolites morphine-6-glucuronide and morphine-6-sulphate. A preferred absorption promoting agent is chitosan but other suitable agents include cationic polymers, bioadhesive agents, surface active agents, fatty acids, chelating agents, mucolytic agents, cyclodextrin, microsphere preparations or combinations thereof.
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