Method of making a porous matrix particle
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United States of America Patent
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May 13, 1997
Issued Date -
N/A
app pub date -
Jun 10, 1993
filing date -
Jan 3, 1985
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Expired
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Abstract
A porous particle having a generally isopycnic density with liquid growth medium, a sponge-like character and a diameter of less than 2 mm which is formed from a homogenous biologically compatible matrix is described. This particle is useful in various systems for culturing anchorage-dependent and -independent cells, and is adaptable to large scale tissue culture which permits harvesting of cell products. The method of making such a particle includes preparing a solution containing a biologically compatible material, forming droplets from the solution, freezing the droplets, drying the droplets by sublimation to form a particle, and crosslinking the biologically compatible material in the particle.
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