Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
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United States of America Patent
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May 20, 1997
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app pub date -
Aug 26, 1993
filing date -
Aug 26, 1993
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Abstract
The present invention provides a novel method of treating localized solid tumors and papilloma in an individual. The method comprises introducing a recombinant adenoviral vector containing the herpes simplex virus-thymidine kinase gene. Subsequently, a prodrug, such as the drug ganciclovir, is administered to the individual. The methods of the present invention may be used to treat several different types of cancers and papillomas, including colon carcinoma, prostate cancer, breast cancer, lung cancer, melanoma, hepatoma, brain and head and neck cancer.
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