N-substituted cycloalkyl and polycycloalkyl .alpha.-substituted Trp-Phe-and phenethylamine derivatives
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United States of America Patent
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May 20, 1997
Issued Date -
N/A
app pub date -
Apr 28, 1994
filing date -
Jun 29, 1989
priority date (Note) -
Expired
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Abstract
Novel unnatural dipeptoids of .alpha.-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, colorectal tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents, antiulcer agents, antidepressant agents, and are agents useful for preventing the withdrawal response produced by chronic treatment or use followed by chronic treatment followed by withdrawal from nicotine, diazepam, alcohol, cocaine, caffeine, or opiods. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare pharmaceutical and diagnostic compositions.
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