Predictive assay for the outcome of IVF
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United States of America Patent
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Jun 3, 1997
Grant Date -
N/A
app pub date -
Sep 21, 1995
filing date -
Mar 23, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides a method for predicting the outcome of IVF which comprises: (i) determining the level of 11.beta.-hydroxysteroid dehydrogenase (11.beta.-HSD) in a biological sample from a female patient; and (ii) predicting from the level of 11.beta.-HSD determined the probability of establishing pregnancy in said subject by IVF. It has been found that there is an inverse correlation between the levels of 11.beta.-HSD in the environment of the oocyte and subsequent establishment of pregnancy by IVF. The present invention also provides methods of screening female subjects for their suitability to take part in IVF programs, and kits to use in determining levels of 11.beta.-HSD.
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