Method of site-specific alteration of RNA and production of encoded polypeptides
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United States of America Patent
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Jun 3, 1997
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N/A
app pub date -
Nov 18, 1994
filing date -
Feb 15, 1990
priority date (Note) -
Expired
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Abstract
A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the method. It further relates to a method of producing polypeptides or proteins encoded by the RNA molecule altered by the present method. Through use of the present method, site-directed cleavage of an RNA molecule is effected, followed by excision of the selected or target segment of the RNA molecule.
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