Electrostatic process for manufacturing coated transplants and product
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United States of America Patent
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Jun 17, 1997
Issued Date -
N/A
app pub date -
Apr 14, 1995
filing date -
May 29, 1992
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An electrostatic process for coating a biological material with a uniform, continuous polymer layer by discharging a suspension of the biological material in a gellable coating polymer solution in a continuous stream through an orifice. The stream is attenuated to form droplets by maintaining an electrostatic voltage between the needle and the gelling solution which is sufficient to maintain an attraction of at least 1.times.10.sup.6 newtons on the stream of liquid leaving the needle, and the droplets are collected in a gelling solution. A preferred product is pancreatic islets having a continuous, smooth coating of high polymannuronate non-fibrogenic alginate having a thickness of at least 10 .mu.m.
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