Method and apparatus for continuously monitoring the concentration of a metabolyte
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United States of America Patent
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Jun 24, 1997
Grant Date -
N/A
app pub date -
May 5, 1995
filing date -
Jan 19, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention is directed to a method and an apparatus for continuously monitoring the concentration of a metabolite, such as glucose or lactic acid, in biological tissue, in which a perfusion fluid is fed to a microdialysis probe implanted in the subcutaneous tissue and removed therefrom as dialysate after enrichment with the metabolites contained in the lymph. An enzyme is added to the dialysate and/or perfusion fluid, and the concentration of the metabolite in the dialysate is determined under the selective effect of the enzyme at a measuring point which is positioned ex vivo, using an electrochemical sensor. The enzyme is added to the dialysate in the form of a continuous enzyme solution flow upstream of the measuring point and in dependence of the throughput of the microdialysis probe.
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