Treatment of osteopetrotic diseases
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United States of America Patent
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Jun 24, 1997
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N/A
app pub date -
Jul 25, 1994
filing date -
Jul 25, 1994
priority date (Note) -
Expired
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Abstract
Bone resorption by osteoclast cells is promoted by activated vitamin D-binding factor, thereby providing an effective treatment for osteopetrosis. Conversely, inflammation-mediated bone loss is inhibited with antibody against the activated factor, providing a treatment for inflammation-mediated osteolytic diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis and periodontal disease. The antibodies are further utilized in an antigen binding assay for diagnosing inflammation-mediated bone loss.
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