US Patent No: 5,643,246

Number of patents in Portfolio can not be more than 2000

Electromagnetically triggered, responsive gel based drug delivery device

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Abstract

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A system for remotely inducing a phase transition in a gel is provided. The system includes a gel capable of volume change in response to an environmental stimulus, a seed material in contact with the gel, and generating a time-varying magnetic or a time-varying electric or electromagnetic field in the proximity of the gel to produce the environmental stimulus. In a preferred embodiment, the environmental stimulus is temperature.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MEDLOGIC GLOBAL LIMITEDCHESHIRE7

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hovorka, George Boston, MA 17 297
Leeb, Steven B Belmont, MA 27 647
Lupton, E C Boston, MA 8 161
Yu, Xiaohong Boston, MA 16 311

Cited Art Landscape

Patent Info (Count) # Cites Year
 
LA CORPORATION DE L'ECOLE POLYTECHNIQUE (1)
* 5,366,454 Implantable medication dispensing device 67 1993
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
* 4,657,543 Ultrasonically modulated polymeric devices for delivering compositions 80 1984
 
Other [Check patent profile for assignment information] (2)
* 4,545,368 Induction heating method for use in causing necrosis of neoplasm 90 1983
* 4,767,611 Method for affecting intracellular and extracellular electric and magnetic dipoles 30 1984
 
CHILDREN'S MEDICAL CENTER CORPORATION (1)
* 5,019,372 Magnetically modulated polymeric drug release system 150 1990
 
SUN WAN KIM (1)
* 5,226,902 Pulsatile drug delivery device using stimuli sensitive hydrogel 69 1991
 
GORDON, DAVID, SKOKIE, ILLINOIS (2)
* 4,662,359 Use of magnetic susceptibility probes in the treatment of cancer 46 1983
* 4,735,796 Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease 83 1985
 
ADVANCED MAGNETICS, INC. (1)
* 4,827,945 Biologically degradable superparamagnetic materials for use in clinical applications 87 1987
 
SENJU PHARMACEUTICAL CO., LTD. (1)
* 5,152,758 Electroresponsive hydrogel and physiologically active substance release control system 68 1990
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
* 2010/0204,647 Electromagnetically Actuated Intracorporeal Drug Delivery 23 2010
 
UNIVERSITY OF ZARAGOZA (1)
* 2011/0230,568 HEATING OF POLYMERS AND OTHER MATERIALS USING RADIATION FOR DRUG DELIVERY AND OTHER APPLICATIONS 1 2009
 
Artemis Medical, Inc. (2)
* 2002/0058,882 Biopsy localization method and device 34 2001
* 2005/0045,192 Biopsy localization method and device 37 2004
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (6)
8,216,259 Compositions and methods for joining non-conjoined lumens 3 2007
* 2008/0045,985 COMPOSITIONS AND METHODS FOR JOINING NON-CONJOINED LUMENS 5 2007
8,608,760 Compositions and methods for joining non-conjoined lumens 0 2007
* 2008/0262,519 COMPOSITIONS AND METHODS FOR JOINING NON-CONJOINED LUMENS 5 2007
8,197,499 Compositions and methods for joining non-conjoined lumens 3 2008
* 2009/0187,199 COMPOSITIONS AND METHODS FOR JOINING NON-CONJOINED LUMENS 4 2008
 
Vascular Control Systems, Inc. (2)
7,983,734 Fibrous marker and intracorporeal delivery thereof 10 2003
* 2004/0236,212 Fibrous marker and intracorporeal delivery thereof 48 2003
 
THE INVENTION SCIENCE FUND I, LLC (26)
8,998,884 Remote controlled in situ reaction method 0 2005
8,585,684 Reaction device controlled by magnetic control signal 0 2005
7,817,030 Remote controller for in situ reaction device 11 2005
* 2007/0106,267 Reaction device controlled by magnetic control signal 1 2005
* 2007/0106,331 Remote controlled in situ reaction device 2 2005
8,273,075 Osmotic pump with remotely controlled osmotic flow rate 10 2005
7,699,834 Method and system for control of osmotic pump device 26 2005
* 2007/0135,800 Method and system for control of osmotic pump device 12 2005
7,942,867 Remotely controlled substance delivery device 11 2006
* 2007/0106,271 Remote control of substance delivery system 12 2006
* 2007/0104,023 Acoustically controlled substance delivery device 12 2006
8,109,923 Osmotic pump with remotely controlled osmotic pressure generation 11 2006
* 2007/0135,801 Osmotic pump with remotely controlled osmotic pressure generation 14 2006
7,819,858 Remote controlled in vivo reaction method 10 2006
* 2007/0106,273 Remote controlled in vivo reaction method 4 2006
8,083,710 Acoustically controlled substance delivery device 11 2008
8,192,390 Method and system for control of osmotic pump device 10 2008
7,896,868 Method and system for control of osmotic pump device 10 2008
* 2009/0024,114 Method and system for control of osmotic pump device 10 2008
* 2009/0018,704 Method and system for control of osmotic pump device 10 2008
8,367,003 Acoustically controlled reaction device 10 2009
8,349,261 Acoustically controlled reaction device 10 2009
* 2009/0162,250 Acoustically controlled reaction device 2 2009
8,273,071 Remote controller for substance delivery system 0 2009
8,172,833 Remote control of substance delivery system 0 2009
8,114,065 Remote control of substance delivery system 10 2009
 
C. R. Bard, Inc. (9)
8,401,622 Biopsy marker with in situ-generated imaging properties 5 2007
8,670,818 Marker delivery device for tissue marker placement 1 2008
8,311,610 Biopsy tissue marker 5 2009
8,437,834 Breast marker 7 2011
9,042,965 Biopsy marker with in situ-generated imaging properties 0 2013
D716450 Tissue marker for intracorporeal site identification 0 2013
D716451 Tissue marker for intracorporeal site identification 0 2013
D715942 Tissue marker for intracorporeal site identification 0 2013
D715442 Tissue marker for intracorporeal site identification 0 2013
 
DAKO DENMARK A/S (1)
* 6,930,292 Method of controlling the temperature of a specimen in or on a solid support member 20 2000
 
DEVICOR MEDICAL PRODUCTS, INC. (1)
8,292,822 Biopsy localization method and device 0 2004
 
FOSTER-MILLER, INC. (1)
8,158,002 Responsive gels and methods of use thereof 1 2000
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (2)
* 2011/0212,027 RADIATIVE HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 0 2009
* 2011/0212,163 MAGNETIC HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 0 2009
 
BATTELLE MEMORIAL INSTITUTE (3)
6,979,464 Reversible geling co-polymer and method of making 11 1998
7,033,571 Multiple stimulus reversible hydrogels 27 2003
* 2004/0096,508 Multiple stimulus reversible hydrogels 5 2003
 
SEARETE LLC (2)
* 2007/0106,277 Remote controller for substance delivery system 3 2006
* 2007/0260,174 Detecting a failure to maintain a regimen 4 2006
 
Bard Peripheral Vascular, Inc. (2)
8,579,931 Apparatus for the percutaneous marking of a lesion 11 2011
8,486,028 Tissue marking apparatus having drug-eluting tissue marker 7 2011
 
BARD SHANNON LIMITED (1)
8,634,899 Multi mode imaging marker 0 2006
 
The United States of America as represented by the Secretary of the Navy (1)
* 6,143,138 Visible light pH change for activating polymers and other pH dependent reactants 9 1998
 
EUROPEAN INSTITUTE OF SCIENCE AB (1)
* 6,739,342 Device for therapeutic purposes on human tissue, for influencing injected magnetic particles with an alternating electro-magnetic gradient field 20 2002
 
GEARBOX, LLC (10)
9,254,256 Remote controlled in vivo reaction method 0 2005
8,617,141 Remote controlled in situ reaction device 0 2005
9,028,467 Osmotic pump with remotely controlled osmotic pressure generation 0 2005
8,998,886 Remote control of osmotic pump device 0 2005
8,882,747 Substance delivery system 0 2006
8,992,511 Acoustically controlled substance delivery device 0 2006
8,936,590 Acoustically controlled reaction device 0 2006
8,529,551 Acoustically controlled substance delivery device 10 2006
8,568,388 Remote controlled in situ reaction device 0 2006
8,968,274 Acoustically controlled substance delivery device 0 2008
 
SenoxRx, Inc. (1)
* 2008/0058,640 Marker formed of starch or other suitable polysaccharide 7 2007
 
TAUTONA GROUP L.P. (3)
8,172,861 Compositions and methods for joining non-conjoined lumens 2 2008
* 2009/0162,438 COMPOSITIONS AND METHODS FOR JOINING NON-CONJOINED LUMENS 5 2008
8,563,037 Compositions and methods for joining non-conjoined lumens 0 2009
 
SENORX, INC. (62)
* 6,161,034 Methods and chemical preparations for time-limited marking of biopsy sites 189 1999
6,427,081 Methods and chemical preparations for time-limited marking of biopsy sites 64 2000
6,497,706 Biopsy device and method of use 27 2000
6,725,083 Tissue site markers for in VIVO imaging 81 2000
6,638,234 Sentinel node location and biopsy 66 2000
6,540,695 Biopsy anchor device with cutter 61 2000
6,679,851 Tissue accessing and anchoring device and method 56 2001
6,662,041 Imageable biopsy site marker 56 2001
7,377,902 Biopsy anchor device with cutter 11 2002
6,716,179 Sentinel node location and biopsy 28 2002
6,567,689 Methods and chemical preparations for time-limited marking of biopsy sites 64 2002
6,862,470 Cavity-filling biopsy site markers 58 2002
6,875,182 Electrosurgical specimen-collection system 2 2002
7,651,505 Plugged tip delivery for marker placement 34 2002
* 2003/0233,101 Plugged tip delivery tube for marker placement 94 2002
6,758,848 Apparatus and method for accessing a body site 18 2002
7,877,133 Marker or filler forming fluid 21 2003
* 2004/0236,211 Marker or filler forming fluid 31 2003
7,047,063 Tissue site markers for in vivo imaging 68 2003
* 2005/0063,908 Tissue site markers for in vivo imaging 15 2003
* 2004/0101,479 Biopsy site marker and process and apparatus for applying it 39 2003
6,996,433 Imageable biopsy site marker 51 2003
* 2004/0116,806 Biopsy site marker and process and apparatus for applying it 10 2003
7,282,034 Tissue accessing and anchoring device and method 1 2003
* 2004/0117,652 Tissue accessing and anchoring device and method 0 2003
* 2004/0236,213 Marker delivery device with releasable plug 55 2004
6,993,375 Tissue site markers for in vivo imaging 53 2004
* 2004/0193,044 Tissue site markers for in vivo imaging 17 2004
7,229,439 Apparatus and method for accessing a body site 6 2004
* 2005/0119,562 Fibrous marker formed of synthetic polymer strands 55 2004
7,792,569 Cavity-filling biopsy site markers 10 2004
* 2005/0143,656 Cavity-filling biopsy site markers 24 2004
7,565,191 Tissue site markers for in vivo imaging 14 2005
* 2006/0155,190 Imageable biopsy site marker 44 2006
8,147,487 Apparatus and method for accessing a body site 0 2007
* 2007/0232,955 Apparatus and method for accessing a body site 1 2007
* 2008/0039,819 Marker formed of starch or other suitable polysaccharide 14 2007
8,360,990 Biopsy device with aperture orientation and improved tip 0 2007
8,343,071 Biopsy device with aperture orientation and improved tip 0 2007
* 2009/0030,309 Deployment of polysaccharide markers 16 2008
7,970,454 Marker delivery device with releasable plug 0 2008
* 2009/0287,078 Marker or filler forming fluid 7 2008
8,224,424 Tissue site markers for in vivo imaging 3 2009
* 2010/0010,342 Tissue site markers for in vivo imaging 10 2009
8,177,792 Plugged tip delivery tube for marker placement 2 2009
8,718,745 Tissue site markers for in vivo imaging 1 2010
8,219,182 Cavity-filling biopsy site markers 3 2010
8,157,862 Tissue marking implant 11 2010
8,447,386 Marker or filler forming fluid 0 2010
8,361,082 Marker delivery device with releasable plug 10 2011
8,498,693 Intracorporeal marker and marker delivery device 0 2011
8,626,269 Fibrous marker and intracorporeal delivery thereof 8 2011
9,149,341 Deployment of polysaccharide markers for treating a site within a patient 0 2011
8,668,737 Tissue marking implant 3 2012
8,784,433 Plugged tip delivery tube for marker placement 0 2012
8,626,270 Cavity-filling biopsy site markers 9 2012
9,044,162 Marker delivery device with releasable plug 0 2013
8,639,315 Marker or filler forming fluid 7 2013
8,880,154 Fibrous marker and intracorporeal delivery thereof 0 2013
8,965,486 Cavity filling biopsy site markers 0 2013
9,039,763 Tissue marking implant 1 2014
9,237,937 Cavity-filling biopsy site markers 0 2015
* Cited By Examiner