Compositions and methods for modulating RNA activity through modification of the 5' cap structure of RNA
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United States of America Patent
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Jul 1, 1997
Issued Date -
N/A
app pub date -
Oct 21, 1994
filing date -
Apr 3, 1992
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Abstract
Methods for regulating gene expression in biological experimental systems via modification or removal of the 5' cap structure of targeted ribonucleic acids are disclosed. Modification or removal of the 5' cap structure is achieved in accordance with preferred embodiments utilizing antisense compounds which are complementary to the 5' terminus of the targeted RNA and have attached to them reactive moieties explicitly designed for chemical modification or cleavage of the 5' cap structure of RNA. Compositions that have utility as research reagents and therapeutics for the treatment of diseases are disclosed.
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