Sterol modified oligonucleotide duplexes having anticancer activity
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United States of America Patent
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Jul 8, 1997
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N/A
app pub date -
Feb 28, 1994
filing date -
Feb 28, 1994
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Abstract
Oligonucleotides having approximately 8 to 18 nucleotide units and a 3'-tail which includes asteroid structure attached to the 3'-end through the A ring of the steroid skeleton and which form substantially stable duplexes at physiological temperature, have selective cytotoxic activity against certain tumor cell lines.
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