DNA encoding antibodies with altered effector functions
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United States of America Patent
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Jul 15, 1997
Issued Date -
N/A
app pub date -
Jun 7, 1995
filing date -
Mar 18, 1987
priority date (Note) -
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Abstract
The DNA encoding an antibody with an altered function, e.g. altered affinity for an effector ligand such as Fc receptor (FcR) on a cell or the Cl component of complement is produced by replacing the nucleic acid encoding at least one amino acid residue in the constant portion of the antibody with nucleic acid encoding a different residue.
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