Fractionated polyalkylene oxide-conjugated hemoglobin solutions
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United States of America Patent
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Jul 22, 1997
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N/A
app pub date -
Jun 30, 1995
filing date -
Nov 22, 1989
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Abstract
Polyalkylene oxide-conjugated hemoglobin solutions having a molecular weight greater than about 85,000 daltons and a degree of substitution of which substantially avoids clinically significant nephrotoxicity associated with hemoglobinuria in mammals. A method of simultaneously fractionating and purifying polyalkylene oxide-conjugated hemoglobins is al so disclosed.
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