Use of nitric oxide releasing compounds as hypoxic cell radiation sensitizers
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United States of America Patent
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Jul 22, 1997
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N/A
app pub date -
Oct 7, 1994
filing date -
Oct 8, 1993
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Abstract
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.
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