Human anti-TNF antibodies
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United States of America Patent
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Aug 5, 1997
Issued Date -
N/A
app pub date -
May 5, 1995
filing date -
Mar 5, 1993
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Abstract
Human monoclonal antibodies (mAbs) which bind to human TNF.alpha. are disclosed. Autoantibodies of both the IgM and IgG isotypes are disclosed. A preferred human monoclonal antibody is known as B5 (F78-1A10-B5 mAb) and it binds to recombinant human TNF.alpha. (rhTNF.alpha.) in ELISA format with a titer comparable to three high affinity neutralizing mouse mAbs. It also binds to cell surface TNF.alpha. and prevents TNF.alpha. secretion by human monocyte cell lines.
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