Pharmaceutical formulations that have a biologically active hydrophilic phase and a chylomicra-containing hydrophobic phase
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United States of America Patent
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Aug 12, 1997
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app pub date -
Feb 16, 1994
filing date -
Sep 29, 1988
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Abstract
Orally or rectally administrable formulations of biologically active material comprise a water-in-oil microemulsion, wherein the hydrophilic phase of the microemulsion comprises the biologically active material and the hydrophobic phase comprises chylomicra or material capable of forming chylomicra in the intestinal mucosa after administration. The biologically active material may be any of a wide range of substances including insulin, calcitonin and somatotrophin or growth hormone. Formulations of the invention are particularly suitable for the oral administration of insulin in the treatment of diabetes.
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